The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 11, 2017

Filed:

Dec. 21, 2015
Applicant:

The Asan Foundation, Seoul, KR;

Inventors:

Gilnam Lee, Seoul, KR;

Hye Sun Jeon, Gyeonggi-Do, KR;

Ki Joon Jeon, Gyeonggi-Do, KR;

Chul Yun Rhim, Seoul, KR;

Jin Sung Kim, Seoul, KR;

Jeongbeob Seo, Gyeonggi-Do, KR;

Suk Young Cho, Chungcheongnam-Do, KR;

Choung Soo Kim, Gyeonggi-Do, KR;

Jung Shin Lee, Seoul, KR;

Eun Kyung Choi, Seoul, KR;

Jung Jin Hwang, Seoul, KR;

Bongcheol Kim, Gyeonggi-Do, KR;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/04 (2006.01); C07D 471/04 (2006.01); C07D 271/10 (2006.01); C07D 271/113 (2006.01); C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 221/04 (2013.01); C07D 271/10 (2013.01); C07D 271/113 (2013.01); C07D 413/04 (2013.01);
Abstract

The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.


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