The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Sep. 30, 2015
Eli Lilly and Company, Indianapolis, IN (US);
William T. McMillen, McCordsville, IN (US);
Sajan Joseph, Carmel, IN (US);
Huaxing Pei, Carmel, IN (US);
Jason Scott Sawyer, Indianapolis, IN (US);
Gaiying Zhao, Westfield, IN (US);
David A. Coates, Indianapolis, IN (US);
Craig D. Wolfangel, Carmel, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFβR1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.