The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
May. 27, 2015
Bristol-myers Squibb Company, Princeton, NJ (US);
Jon J. Hangeland, Morrisville, PA (US);
Mimi L. Quan, Yardley, PA (US);
Joanne M. Smallheer, Yardley, PA (US);
Gregory S. Bisacchi, Newton Highlands, MA (US);
James R. Corte, Lawrenceville, NJ (US);
Todd J. Friends, Bordentown, NJ (US);
Zhong Sun, San Diego, CA (US);
Karen A. Rossi, Newtown, PA (US);
Cullen L. Cavallaro, Robbinsville, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R, R, R, R, X, X, and Xare as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.