The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Aug. 15, 2012
Applicants:
Michael W. Burnet, Tübingen, DE;
Jan-hinrich Guse, Tubingen-Buhl, DE;
Christiane Bauerlein, Ofterdingen, DE;
Ulrike Hahn, Ditzingen, DE;
Inventors:
Michael W. Burnet, Tübingen, DE;
Jan-Hinrich Guse, Tubingen-Buhl, DE;
Christiane Bauerlein, Ofterdingen, DE;
Ulrike Hahn, Ditzingen, DE;
Assignee:
Synovo GmbH, Tubingen, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/38 (2006.01); A61K 31/415 (2006.01); C07H 13/02 (2006.01); C07D 471/04 (2006.01); C07D 417/04 (2006.01); A61K 31/4439 (2006.01); A61K 31/519 (2006.01); C07D 401/04 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 231/38 (2013.01); A61K 31/415 (2013.01); A61K 31/4439 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61K 47/481 (2013.01); C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07H 13/02 (2013.01);
Abstract
A method of treating cancer in which a compound that inhibits the expression, production or release of IL-10 by immune cells is combined with a compound that stimulates the production of IL-12 when given in combination with, or in the presence of TNFa. Said method is effective when provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.