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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9616101 B1

PDFFull Text
Date of Patent:
Apr. 11, 2017

Filed:

Jul. 03, 2013

Differentiation marker and differentiation control of eye cell

Applicants:

Kyoto Prefectural Public University Corporation, Kamigyo-ku, Kyoto-shi, Kyoto, JP;

The Doshisha, Kamigyo-ku, Kyoto-shi, Kyoto, JP;

Senju Pharmaceutical Co., Ltd., Osaka-shi, Osaka, JP;

Inventors:

Takahiro Nakamura, Kyotanabe, JP;

Noriko Koizumi, Kyotanabe, JP;

Naoki Okumura, Kyotanabe, JP;

Shigeru Kinoshita, Kyoto, JP;

Kana Tominaga, Kyoto, JP;

Satoshi Kawasaki, Kyoto, JP;

Assignees:

KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, Kyoto, JP;

THE DOSHISHA, Kyoto, JP;

SENJU PHARMACEUTICAL CO., LTD., Osaka, JP;

Attorney:

Clark Sullivan

Primary Examiner:

Hasan Ahmed

Assistant Examiner:

Thea D'Ambrosio

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 39/00 (2006.01); C07K 14/47 (2006.01); C07K 14/785 (2006.01); C07K 14/005 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); A61K 35/30 (2015.01); G01N 33/569 (2006.01); C12N 5/079 (2010.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 35/30 (2013.01); A61K 48/00 (2013.01); C07K 14/705 (2013.01); C12N 5/0621 (2013.01); C12Q 1/6881 (2013.01); G01N 33/56966 (2013.01); A61K 38/00 (2013.01); C12N 2501/40 (2013.01); C12N 2501/415 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/726 (2013.01); G01N 2800/16 (2013.01);
Abstract

The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.

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