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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9615910 B1

PDFFull Text
Date of Patent:
Apr. 11, 2017

Filed:

May. 29, 2015

Layered collagen and ha scaffold suitable for osteochondral repair

Applicant:

Royal College of Surgeons IN Ireland, Dublin, IE;

Inventors:

John P. Gleeson, Dublin, IE;

Tanya J. Levingstone, Wicklow, IE;

Fergal J. O'Brien, Dublin, IE;

Assignee:

ROYAL COLLEGE OF SURGEONS IN IRELAND, Dublin, IE;

Attorneys:

Nixon Peaobdy LLP

David S. Resnick

Primary Examiner:

Carlos Azpuru

Int. Cl.
CPC ...
A61L 15/28 (2006.01); A61F 2/02 (2006.01); A61L 15/32 (2006.01); A61L 27/24 (2006.01); A61L 27/42 (2006.01); A61L 27/46 (2006.01); A61L 27/56 (2006.01); A61L 27/20 (2006.01); A61L 27/26 (2006.01); A61L 27/12 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61F 2/02 (2013.01); A61L 15/28 (2013.01); A61L 15/325 (2013.01); A61L 27/12 (2013.01); A61L 27/20 (2013.01); A61L 27/24 (2013.01); A61L 27/26 (2013.01); A61L 27/3612 (2013.01); A61L 27/3691 (2013.01); A61L 27/3821 (2013.01); A61L 27/425 (2013.01); A61L 27/46 (2013.01); A61L 27/56 (2013.01); C12N 5/0654 (2013.01); A61F 2210/0076 (2013.01); A61L 2430/02 (2013.01); C12N 2533/54 (2013.01); C12N 2535/00 (2013.01);
Abstract

The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilizing the suspension to provide a first layer; optionally preparing a further suspension of collagen and adding the further suspension onto the layer formed in the previous step to form a further layer, and freezing or lyophilizing the layers, wherein when the layer formed in the previous step is formed by lyophilization the lyophilized layer is re-hydrated prior to addition of the next layer; optionally, repeating the aforementioned step to form one or more further layers; and preparing a final suspension of collagen and pouring the final suspension onto the uppermost layer to form a final layer, and freeze-drying the layers to form the multi-layer collagen composite scaffold.

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