The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2017
Filed:
May. 20, 2014
Instytut Biochemii I Biofizyki Polskiej Akademii Nauk, Warsaw, PL;
Oncoarendi Therapeutics Sp Zoo, Warsaw, PL;
Miedzynarodowy Instytut Biologii Molekularnej I Komorkowej W Warszawie, Warsaw, PL;
Andrzej Dziembowski, Warsaw, PL;
Rafal Tomecki, Warsaw, PL;
Karolina Drazkowska, Warsaw, PL;
Roman Szczesny, Warsaw, PL;
Krystian Stodus, Warsaw, PL;
Weronika Jonko, Warsaw, PL;
Marcin Nowotny, Warsaw, PL;
Adam Golebiowski, Warsaw, PL;
Jacek Olczak, Lodz, PL;
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK, Warsaw, PL;
ONCOARENDI THERAPEUTICS SP ZOO, Warsaw, PL;
MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE, Warsaw, PL;
Abstract
The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell.