The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2017
Filed:
Aug. 04, 2011
Wilhelmina M. C. Van Roon-mom, Beverwijk, NL;
Melvin Maurice Evers, Utrecht, NL;
Barry Antonius Pepers, Leiden, NL;
Annemieke Aartsma-rus, Hoofddorp, NL;
Garrit-jan Boudewijn Van Ommen, Amsterdam, NL;
Wilhelmina M. C. van Roon-Mom, Beverwijk, NL;
Melvin Maurice Evers, Utrecht, NL;
Barry Antonius Pepers, Leiden, NL;
Annemieke Aartsma-Rus, Hoofddorp, NL;
Garrit-Jan Boudewijn Van Ommen, Amsterdam, NL;
Academisch Ziekenhuis Leiden, Leiden, NL;
Abstract
Described are means and methods for removing a proteolytic cleavage site from a protein, the method comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, and allowing translation of mRNA produced from the pre-mRNA.