The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2017
Filed:
May. 03, 2013
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Harold G. Selnick, Harleyville, PA (US);
Wenping Li, Lansdale, PA (US);
Eric Hostetler, Collegeville, PA (US);
Kun Liu, Needham, MA (US);
Ernest J. McEachern, British Columbia, CA;
Yuanxi Zhou, British Columbia, CA;
Zhongyong Wei, Beijing, CN;
Changwei Mu, Beijing, CN;
Yaode Wang, Beijing, CN;
Jiang Chang, Beijing, CN;
ALECTOS THERAPEUTICS, INC., Burnaby, British Columbia, CA;
MERCK SHARP & DOHME CORP., Rahway, NJ (US);
Abstract
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.