The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2017
Filed:
Aug. 23, 2013
Applicant:
The Scripps Research Institute, LaJolla, CA (US);
Inventor:
Dale Boger, LaJolla, CA (US);
Assignee:
SCRIPPS RESEARCH INSTITUTE, Lajolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/04 (2006.01); C07D 487/18 (2006.01); C07D 471/14 (2006.01); C07D 471/22 (2006.01);
U.S. Cl.
CPC ...
C07D 487/18 (2013.01); C07D 471/14 (2013.01); C07D 471/22 (2013.01); C07D 519/04 (2013.01);
Abstract
A vinca alkaloid compound that is substituted at the 20'-position with a urea or thiourea group is disclosed. The urea's proximal nitrogen atom bonded to the 20′-position carbon atom is secondary, whereas the distal nitrogen atom can be unsubstituted only when the compound contains an optionally present 10′-fluoro substituent, and is otherwise preferably mono- or di-substituted. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using a compound.