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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9611251 B1

PDFFull Text
Date of Patent:
Apr. 04, 2017

Filed:

Mar. 12, 2014

Substituted piperidine compounds and their use as orexin receptor modulators

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Heather R. Coate, San Diego, CA (US);

Curt A. Dvorak, Poway, CA (US);

Cathy Preville, La Jolla, CA (US);

Brock T. Shireman, Poway, CA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Baker & Hostetler LLP

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A01N 43/58 (2006.01); A01N 43/60 (2006.01); A61K 31/50 (2006.01); A61K 31/495 (2006.01); A01N 43/54 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); A61K 31/505 (2006.01); A01N 43/40 (2006.01); A61K 31/445 (2006.01); C07D 401/00 (2006.01); C07D 403/00 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention is directed to compounds of Formula I: wherein X is CRor N; Y is CRor N; Z is NH or O; Ris alkoxy, triazolyl, oxazolyl, isoxazolyl, oxadiazolyl, or pyrimidinyl; Ris H, alkyl, or halo; Ris H, alkyl, alkoxy, halo, triazolyl, oxazolyl, or pyrimidinyl; Ris alkyl; Ris pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl; wherein the pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl is optionally substituted with one or two substituents independently selected from the group consisting of alkyl, halo, or phenyl; and Ris H or alkyl. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods using the compounds of the invention are also within the scope of the invention.

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