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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9611201 B1

PDFFull Text
Expired
Date of Patent:
Apr. 04, 2017

Filed:

Mar. 03, 2016

Processes for preparing (r)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone

Applicant:

Karos Pharmaceuticals, Inc., New Haven, CT (US);

Inventors:

Stéphane De Lombaert, Brisbane, CA (US);

Daniel R. Goldberg, Redding, CT (US);

Assignee:

Karos Pharmaceuticals, Inc., New Haven, CT (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Sudhakar Katakam

Assistant Examiner:

Ana Z Muresan

Int. Cl.
CPC ...
C07C 29/32 (2006.01); C07C 29/143 (2006.01); C07C 259/10 (2006.01); C07C 45/45 (2006.01); C07C 49/80 (2006.01);
U.S. Cl.
CPC ...
C07C 29/32 (2013.01); C07C 29/143 (2013.01); C07C 45/455 (2013.01); C07C 49/80 (2013.01); C07C 259/10 (2013.01); C07B 2200/07 (2013.01);
Abstract

The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

Find Patent Forward Citations

De Lombaert, Stéphane. (2017). Processes for preparing (r)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone (U.S. Patent No. 9611201). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9611201

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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