The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Nov. 09, 2012
Cadess Medical Ab, Uppsala, SE;
Jimmy C. Azar, Uppsala, SE;
Christer Busch, Uppsala, SE;
Ingrid B. Carlbom, Uppsala, SE;
Milan Gavrilovic, Uppsala, SE;
CADESS MEDICAL AB, Uppsala, SE;
Abstract
The method according to the invention generates a color decomposition of histological tissue image data into density maps, where each density map corresponds to the portion of the original image data that contains one stain/tissue combination. After a microscope captures histological tissue image data from a tissue sample that has been stained with at least one stain, the said stain or stains being light absorbent, the method derives from the histological tissue image data a color mixing matrix with the columns of the matrix being color reference vectors. From this mixing matrix the method derives a density map, when the mixing matrix is well-conditioned, by applying a pseudo-inverse of the mixing matrix to the optical density data, and when the mixing matrix is medially-conditioned, by applying a piece-wise pseudo-inverse of the mixing matrix to the optical density data. The method according to the invention also generates stain/tissue combination efficacy measures.