The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Apr. 03, 2012
Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
Applicants:
Thomas Ming Hung Lee, Hong Kong, CN;
Kwun Fung Wong, Hong Kong, CN;
Shea Ping Yip, Hong Kong, CN;
Inventors:
Assignee:
The Hong Kong Polytechnic University, Hung Hom, Kowloon, HK;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); B82Y 5/00 (2011.01); B82Y 15/00 (2011.01);
U.S. Cl.
CPC ...
C12Q 1/6844 (2013.01); B82Y 5/00 (2013.01); B82Y 15/00 (2013.01);
Abstract
A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions.