The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Jan. 29, 2010
Marcel Blot-chabaud, Fuveau, FR;
Karim Harhouri, Marseilles, FR;
Nathalie Bardin, Marseilles, FR;
Benjamin Guillet, Aix en Provence, FR;
Françoise Dignat-george, Marseilles, FR;
Marcel Blot-Chabaud, Fuveau, FR;
Karim Harhouri, Marseilles, FR;
Nathalie Bardin, Marseilles, FR;
Benjamin Guillet, Aix en Provence, FR;
Françoise Dignat-George, Marseilles, FR;
UNIVERSITE D'AIX-MARSEILLE, Marseilles, FR;
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;
Abstract
The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD 146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.