The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Feb. 06, 2012
Paul Greengard, New York, NY (US);
Wenjie Luo, New York, NY (US);
Gen He, New York, NY (US);
Peng LI, New York, NY (US);
Lawrence Wennogle, New York, NY (US);
Paul Greengard, New York, NY (US);
Wenjie Luo, New York, NY (US);
Gen He, New York, NY (US);
Peng Li, New York, NY (US);
Lawrence Wennogle, New York, NY (US);
INTRA-CELLULAR THERAPIES, INC., New York, NY (US);
THE ROCKEFELLER UNIVERSITY, New York, NY (US);
Abstract
The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates γ-secretase to produce β-amyloid protein (Aβ). Deposition of Aβ has been associated with Alzheimer's disease and other pathologies. The invention thus additionally provides, e.g., screening methods and novel research tools, inhibitors of this novel protein, and methods of diagnosis, treatment and control of Alzheimer's disease and other neurodegenerative conditions associated with deposition of Aβ.