The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Oct. 26, 2015
Grant Gallagher, Milltown, NJ (US);
Raymond Yu, East Brunswick, NJ (US);
Jonathan Brazaitis, Parlin, NJ (US);
Grant Gallagher, Milltown, NJ (US);
Raymond Yu, East Brunswick, NJ (US);
Jonathan Brazaitis, Parlin, NJ (US);
Medical Diagnostic Laboratories, LLC, Hamilton, NJ (US);
Abstract
The present invention relates to novel linear and cyclic polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WXXXW, where W is tryptophan, and X, Xand Xare amino acids, with the proviso that when one of X, Xor Xis W, the remaining two of X, Xor Xcannot be W. Preferred core structures include WVDYW or WQDYW. The present invention relates a composition containing the novel polypeptides (linear or cyclic), and use of same in inhibiting cell functions including production of IL-22 and IL-17F from immune cells as well as in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease, ulcerative colitis and multiple sclerosis.