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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9605017 B1

PDFFull Text
Expired
Date of Patent:
Mar. 28, 2017

Filed:

Mar. 04, 2014

2', 5′-dideoxy-5-fluorouridine derivatives having cytotoxic activity, a process for the manufacture thereof and application thereof

Applicant:

Adam Mickiewicz University, Pozna{umlaut over (n)}, PL;

Inventors:

Lech Celewicz, Poznań, PL;

Karol Kacprzak, Pecna, PL;

Marta Lewandowska, {umlaut over (S)}rem, PL;

Piotr Ruszkowski, Suchy Las, PL;

Natalia Kleczewska, Pozna{umlaut over (n)}, PL;

Assignee:

ADAM MICKIEWICZ UNIVERSITY, Poznañ, PL;

Attorney:

Oliff PLC

Primary Examiner:

Patrick Lewis

Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 19/06 (2006.01); A61K 31/7072 (2006.01); A61K 31/7068 (2006.01); A61K 31/7064 (2006.01); A61K 31/706 (2006.01);
U.S. Cl.
CPC ...
C07H 19/06 (2013.01); A61K 31/706 (2013.01); A61K 31/7064 (2013.01); A61K 31/7068 (2013.01); A61K 31/7072 (2013.01);
Abstract

The subject matter of the invention is novel 2',5′-dideoxy-5-fluorouridine derivatives of general formula 1. wherein Rdenotesalkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

Find Patent Forward Citations

Celewicz, Lech. (2017). 2', 5′-dideoxy-5-fluorouridine derivatives having cytotoxic activity, a process for the manufacture thereof and application thereof (U.S. Patent No. 9605017). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9605017

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