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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9604998 B1

PDFFull Text
Date of Patent:
Mar. 28, 2017

Filed:

Feb. 12, 2014

Inhibitors of the renal outer medullary potassium channel

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Alexander Pasternak, Princeton, NJ (US);

Reynalda Keh DeJesus, East Brunswick, NJ (US);

Fa-Xiang Ding, Staten Island, NY (US);

Shuzhi Dong, Plainsboro, NJ (US);

Jessica L. Frie, Harleysville, PA (US);

Xin Gu, Scotch Plains, NJ (US);

Jinlong Jiang, Scotch Plains, NJ (US);

Aurash Shahripour, Iselin, NJ (US);

Barbara Pio, West Orange, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Shawn Walsh, Bridgewater, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Baerbel R. Brown

Catherine D. Fitch

Primary Examiner:

Craig Ricci

Int. Cl.
CPC ...
A61K 31/401 (2006.01); C07D 498/04 (2006.01); A61K 31/5383 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 31/403 (2006.01); A61K 31/41 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/4422 (2006.01); A61K 31/4985 (2006.01); A61K 31/55 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/401 (2013.01); A61K 31/403 (2013.01); A61K 31/41 (2013.01); A61K 31/4178 (2013.01); A61K 31/4184 (2013.01); A61K 31/4422 (2013.01); A61K 31/4985 (2013.01); A61K 31/5383 (2013.01); A61K 31/55 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.

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