The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Mar. 13, 2015
Applicant:
The Research Foundation for Mental Hygiene, Inc., Menands, NY (US);
Inventor:
Cheng-Xin Gong, Staten Island, NY (US);
Assignee:
THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, Menands, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/28 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/28 (2013.01); A61K 9/0043 (2013.01);
Abstract
Intranasal administration of insulin for a predetermined period prior to anesthesia significantly prevented anesthesia-induced tau hyperphosphorylation and cognitive impairment and enhanced brain insulin signaling in mice. Intranasal insulin thus provides a treatment for prevention of anesthesia-induced tau pathology and increased risk for tauopathies in surgical patients and may be administered to a subject prior to anesthesia, such as by administering several doses of intranasal insulin for several consecutive days prior to any anesthesia.