The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Nov. 08, 2011
Applicants:
Lan Cao, Stoughton, MA (US);
Kamal H. Bouhadir, Beirut, LB;
David J. Mooney, Sudbury, MA (US);
Inventors:
Assignee:
President and Fellows of Harvard College, Cambridge, MS (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 38/17 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/10 (2013.01); A61K 38/1709 (2013.01); A61K 47/4823 (2013.01); A61K 47/48246 (2013.01);
Abstract
The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.