The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Apr. 03, 2015
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Xiaodong Wang, Chapel Hill, NC (US);
Stephen Frye, Chapel Hill, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/519 (2006.01); C07D 487/00 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/505 (2006.01); A61K 31/551 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/505 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 31/5513 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01);
Abstract
The present invention includes pyrazolopyrimidine compounds of Formula I that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrazolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.