The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2017

Filed:

Nov. 24, 2015
Applicant:

Cadila Healthcare Limited, Ahmedabad, IN;

Inventors:

Brij Khera, Ahmedabad, IN;

Kumar Kamlesh Singh, Ahmedabad, IN;

Santosh Devidas Diwakar, Ahmedabad, IN;

Sunil Dnyaneshwar Narode, Ahmedabad, IN;

Hiteshkumar Natwarlal Suthar, Ahmedabad, IN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/451 (2006.01); A61K 45/06 (2006.01); C07D 471/04 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/451 (2013.01); A61K 31/00 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01);
Abstract

A crystalline Form N-1 of apixaban substantially free from one or more of: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; or methyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, relative to apixaban by area percentage of HPLC and having a mean particle size equal to or greater than 100 μm.


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