The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2017
Filed:
Mar. 02, 2015
Applicant:
Novartis Ag, Basel OT, CH;
Inventors:
Gary Mark Coppola, Budd Lake, NJ (US);
Yuki Iwaki, Tokyo, JP;
Rajeshri Karki, Somerville, MA (US);
Toshio Kawanami, Boston, MA (US);
Gary Michael Ksander, Amherst, NH (US);
Muneto Mogi, Waltham, MA (US);
Robert Sun, Natick, MA (US);
Assignee:
NOVARTIS AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/194 (2006.01); C07C 233/47 (2006.01); C07C 233/63 (2006.01); C07C 233/87 (2006.01); C07C 235/52 (2006.01); C07C 251/12 (2006.01); C07C 257/06 (2006.01); C07C 271/12 (2006.01); C07C 275/16 (2006.01); C07C 311/19 (2006.01); C07C 317/44 (2006.01); C07C 235/82 (2006.01); C07D 207/34 (2006.01); C07D 209/18 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 231/14 (2006.01); C07D 239/28 (2006.01); C07D 271/10 (2006.01); C07D 277/64 (2006.01); C07D 285/12 (2006.01); C07D 303/48 (2006.01); C07D 307/68 (2006.01); C07D 309/40 (2006.01); C07D 333/24 (2006.01); C07D 333/40 (2006.01); C07D 261/18 (2006.01); A61K 45/06 (2006.01); C07C 235/74 (2006.01);
U.S. Cl.
CPC ...
A61K 31/194 (2013.01); A61K 45/06 (2013.01); C07C 233/47 (2013.01); C07C 233/63 (2013.01); C07C 233/87 (2013.01); C07C 235/52 (2013.01); C07C 235/74 (2013.01); C07C 235/82 (2013.01); C07C 251/12 (2013.01); C07C 257/06 (2013.01); C07C 271/12 (2013.01); C07C 275/16 (2013.01); C07C 311/19 (2013.01); C07C 317/44 (2013.01); C07D 207/34 (2013.01); C07D 209/18 (2013.01); C07D 213/56 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 231/14 (2013.01); C07D 239/28 (2013.01); C07D 261/18 (2013.01); C07D 271/10 (2013.01); C07D 277/64 (2013.01); C07D 285/12 (2013.01); C07D 303/48 (2013.01); C07D 307/68 (2013.01); C07D 309/40 (2013.01); C07D 333/24 (2013.01); C07D 333/40 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/14 (2013.01);
Abstract
The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R, R, R, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.