The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2017

Filed:

Sep. 19, 2014
Applicants:

Christine Lang, Berlin, DE;

Andreas Raab, Berlin, DE;

Inventors:

Christine Lang, Berlin, DE;

Andreas Raab, Berlin, DE;

Assignee:

ORGANOBALANCE GMBH, Berlin, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/81 (2006.01); C12P 7/64 (2006.01); A61K 8/99 (2006.01); A61Q 19/00 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12P 5/00 (2006.01); C12P 33/00 (2006.01); C12N 9/04 (2006.01);
U.S. Cl.
CPC ...
C12P 7/6463 (2013.01); A61K 8/99 (2013.01); A61Q 19/00 (2013.01); C12N 9/0006 (2013.01); C12N 9/0071 (2013.01); C12N 9/1007 (2013.01); C12N 9/1029 (2013.01); C12N 15/81 (2013.01); C12P 5/007 (2013.01); C12P 7/649 (2013.01); C12P 7/6436 (2013.01); C12P 33/00 (2013.01); C12Y 101/01034 (2013.01); C12Y 203/0102 (2013.01); C12Y 203/01026 (2013.01); Y02E 50/343 (2013.01); Y02P 20/52 (2015.11);
Abstract

The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.


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