The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
Mar. 12, 2012
Luis Garcia, Noisy-le-Roi, FR;
Cyriaque Beley, Fontenay le Fleury, FR;
Thomas Voit, London, GB;
Robert Michael Kotin, Bethesda, MD (US);
Lina LI, Potomac, MD (US);
Luis Garcia, Noisy-le-Roi, FR;
Cyriaque Beley, Fontenay le Fleury, FR;
Thomas Voit, London, GB;
Robert Michael Kotin, Bethesda, MD (US);
Lina Li, Potomac, MD (US);
Abstract
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.