The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
May. 07, 2012
Yoshikazu Kurosawa, Aichi, JP;
Kazuhiro Morishita, Miyazaki, JP;
Lilin Zhang, Tokyo, JP;
Gene Kurosawa, Aichi, JP;
Katsuyuki Mitomo, Tokyo, JP;
Yukio Sudo, Tokyo, JP;
Fumiko Nomura, Saitama, JP;
Yoshinori Ukai, Aichi, JP;
Yoshikazu Kurosawa, Aichi, JP;
Kazuhiro Morishita, Miyazaki, JP;
Lilin Zhang, Tokyo, JP;
Gene Kurosawa, Aichi, JP;
Katsuyuki Mitomo, Tokyo, JP;
Yukio Sudo, Tokyo, JP;
Fumiko Nomura, Saitama, JP;
Yoshinori Ukai, Aichi, JP;
PERSEUS PROTEOMICS INC., Tokyo, JP;
UNIVERSITY OF MIYAZAKI, Miyazaki-Shi, JP;
Abstract
An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).