The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
Aug. 14, 2013
Applicant:
The Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Victoria, AU;
Inventors:
Kathleen McCaffrey, Utrecht, NL;
Heidi Drummer, Glenroy, AU;
Pantelis Poumbourios, Williamstown, AU;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61K 39/12 (2006.01); A61K 39/29 (2006.01); C07K 16/10 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); A61K 39/29 (2013.01); C07K 16/109 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55577 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C12N 2770/24222 (2013.01); C12N 2770/24234 (2013.01);
Abstract
The invention provides modified hepatitis C virus (HCV) E2 glycoproteins comprising the HCV-E2 receptor-binding domain (RBD) including the HVR1, HVR2 and igVR variable regions wherein in at least one of said variable regions at least a part of the variable region is replaced with a flexible linker sequence. The invention also provides vaccine compositions comprising the modified glycoproteins as well as methods of use thereof.