The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2017

Filed:

Mar. 30, 2015
Applicant:

Cepheid, Sunnyvale, CA (US);

Inventors:

Alexander A. Gall, Woodinville, WA (US);

Sergey G. Lokhov, Bothell, WA (US);

Mikhail A. Podyminogin, Lake Forest Park, WA (US);

Ekaterina V. Viazovkina, Lynnwood, WA (US);

Kevin Patrick Lund, Lynnwood, WA (US);

Assignee:

Cepheid, Sunnyvale, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/04 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C07H 19/10 (2006.01); C12N 15/11 (2006.01); C07H 19/06 (2006.01); C07K 5/065 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); C07H 19/06 (2013.01); C07K 5/06078 (2013.01); C12N 15/11 (2013.01); C12N 15/111 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6858 (2013.01); C12N 2310/311 (2013.01); C12N 2310/312 (2013.01); C12N 2310/314 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3125 (2013.01); C12N 2310/3181 (2013.01); C12N 2310/32 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/334 (2013.01); C12N 2310/3513 (2013.01); C12N 2320/52 (2013.01);
Abstract

Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified cytosine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.


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