The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2017

Filed:

Mar. 30, 2015
Applicant:

Cepheid, Sunnyvale, CA (US);

Inventors:

Alexander A. Gall, Woodinville, WA (US);

Sergey G. Lokhov, Bothell, WA (US);

Mikhail A. Podyminogin, Lake Forest Park, WA (US);

Ekaterina V. Viazovkina, Lynnwood, WA (US);

Kevin Patrick Lund, Lynnwood, WA (US);

Assignee:

Cepheid, Sunnyvale, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/04 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07F 9/6574 (2006.01); C07K 14/00 (2006.01); C07H 19/073 (2006.01);
U.S. Cl.
CPC ...
C07H 19/06 (2013.01); C07F 9/65744 (2013.01); C07H 19/073 (2013.01); C07H 19/10 (2013.01); C07H 21/04 (2013.01); C07K 14/003 (2013.01); C12Q 1/6813 (2013.01);
Abstract

Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.


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