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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9598440 B1

PDFFull Text
Date of Patent:
Mar. 21, 2017

Filed:

Oct. 03, 2013

Inhibitors of irak4 activity

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

W. Michael Seganish, Scotch Plains, NJ (US);

William T. McElroy, Plainfield, NJ (US);

Stephanie Brumfield, Cranbury, NJ (US);

R. Jason Herr, Voorheesville, NY (US);

Larry Yet, Mobile, AL (US);

Jinhai Yang, Guilderland, NY (US);

James P. Harding, III, Rensselaer, NY (US);

Ginny Dai Ho, Murray Hill, NJ (US);

Deen Tulshian, Lebanon, NJ (US);

Wensheng Yu, Edison, NJ (US);

Michael K.C. Wong, Somerset, NJ (US);

Brian Lavey, New Providence, NJ (US);

Joseph A. Kozlowski, Princeton, NJ (US);

Assignee:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

Attorneys:

Matthew A. Leff

John C. Todaro

Primary Examiner:

Alexander R Pagano

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/4436 (2006.01); A61K 45/06 (2006.01); C07D 513/04 (2006.01); C07D 405/14 (2006.01); C07D 401/04 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 403/04 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/444 (2013.01); A61K 31/4436 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

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