The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
Feb. 05, 2014
Applicant:
Alphavax, Inc., Raleigh, NC (US);
Inventors:
Vernon McNeil Coffield, III, Raleigh, NC (US);
Kurt I. Kamrud, Apex, NC (US);
Jonathan F. Smith, Cary, NC (US);
Assignee:
ALPHAVAX, INC., Raleigh, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01); A61K 39/12 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); A61K 2039/5258 (2013.01); C12N 2770/36143 (2013.01); C12N 2800/40 (2013.01); C12N 2800/50 (2013.01); C12N 2820/60 (2013.01);
Abstract
Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA target sequence is located in the untranslated or translated region of the nucleic acid encoding the viral protein. Also provided are vector systems, compositions and cells comprising the provided helper nucleic acids and a vector or replicon. Methods of making virus-like replicon particles and populations of virus-like replicon particles (VRP) are also provided.