The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2017

Filed:

Jun. 02, 2015
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Scott X. Atwood, Stanford, CA (US);

Anthony Oro, Stanford, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/713 (2006.01); A61K 38/10 (2006.01); G01N 33/574 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07D 403/12 (2006.01); C07D 491/107 (2006.01); C07D 211/40 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 38/10 (2013.01); A61K 31/713 (2013.01); C07D 211/40 (2013.01); C07D 403/12 (2013.01); C07D 491/107 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C12N 15/1137 (2013.01); C12Y 207/11013 (2013.01); G01N 33/5743 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); G01N 2333/912 (2013.01); G01N 2440/14 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract

Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.


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