The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
Oct. 03, 2011
Applicants:
Jeremy J. Mao, Closter, NJ (US);
MO Chen, New York, NY (US);
Inventors:
Jeremy J. Mao, Closter, NJ (US);
Mo Chen, New York, NY (US);
Assignee:
The Trustees of Columbia University in the City of New York, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/32 (2015.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); C12N 5/071 (2010.01); A61K 35/28 (2015.01); A61K 35/36 (2015.01); A61K 35/51 (2015.01); A61K 35/545 (2015.01); A23L 33/10 (2016.01);
U.S. Cl.
CPC ...
A61K 35/32 (2013.01); A23L 33/10 (2016.08); A61K 35/28 (2013.01); A61K 35/36 (2013.01); A61K 35/51 (2013.01); A61K 35/545 (2013.01); C12N 5/0654 (2013.01); C12N 5/0664 (2013.01); C12N 5/0697 (2013.01); A23V 2002/00 (2013.01); C12N 2500/38 (2013.01); C12N 2501/39 (2013.01); C12N 2501/415 (2013.01); C12N 2501/998 (2013.01); C12N 2502/13 (2013.01); C12N 2502/1311 (2013.01); C12N 2502/1364 (2013.01); C12N 2533/18 (2013.01);
Abstract
Described is a method of forming a mineralized material by co-culturing epithelial cell, such as ameloblast, and mesenchymal cell, such as osteoblast or odontoblast, in a mineral-stimulating medium. Also described is a matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix. Methods of manufacturing such compositions and methods of treating mineralization-related conditions are also described.