The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2017
Filed:
Nov. 11, 2014
Deirdre Meldrum, Phoenix, AZ (US);
Laimonas Kelbauskas, Gilbert, AZ (US);
Jeff Houkal, Los Angeles, CA (US);
Roger Johnson, Phoenix, AZ (US);
Yanqing Tian, Tempe, AZ (US);
Cody Youngbull, Tempe, AZ (US);
Deirdre Meldrum, Phoenix, AZ (US);
Laimonas Kelbauskas, Gilbert, AZ (US);
Jeff Houkal, Los Angeles, CA (US);
Roger Johnson, Phoenix, AZ (US);
Yanqing Tian, Tempe, AZ (US);
Cody Youngbull, Tempe, AZ (US);
Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US);
Abstract
Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.