The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2017

Filed:

Feb. 07, 2014
Applicants:

Polyphor Ltd., Allschwil, CH;

Universitaet Zuerich, Zurich, CH;

Inventors:

Steven J. Demarco, Dietgen, CH;

Wim Vrijbloed, Moehlin, CH;

Ricardo Dias, Binningen, CH;

John Anthony Robinson, Wermatswil, CH;

Nityakalyani Srinivas, Basel, CH;

Frank Gombert, Huttingen, DE;

Daniel Obrecht, Baettwil, CH;

Assignees:

POLYPHOR LTD., Allschwil, CH;

UNIVERSITAET ZUERICH, Zurich, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); A01N 43/36 (2006.01); C07K 1/10 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
A01N 43/36 (2013.01); C07K 1/10 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 7/64 (2013.01); C07K 14/001 (2013.01);
Abstract

Template-fixed β-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.


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