The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Feb. 11, 2009
David M. Hoganson, Boston, MA (US);
Joseph P. Vacanti, Winchester, MA (US);
Jeffrey T. Borenstein, Newton, MA (US);
David M. Hoganson, Boston, MA (US);
Joseph P. Vacanti, Winchester, MA (US);
Jeffrey T. Borenstein, Newton, MA (US);
The General Hospital, Boston, MA (US);
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
Abstract
The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.