The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Apr. 15, 2014
Applicant:
4-antibody Ag, Basel, CH;
Inventors:
Ulf Grawunder, U.G. Hersberg, CH;
Jorn Stitz, Basel, CH;
Assignee:
AGENUS INC., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); C12N 15/10 (2006.01); C07K 14/435 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C12N 9/78 (2006.01); G01N 33/569 (2006.01); C12N 5/0781 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C07K 14/43595 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C12N 5/0635 (2013.01); C12N 9/78 (2013.01); G01N 33/56966 (2013.01); G01N 33/56972 (2013.01); C07K 2317/21 (2013.01); C40B 30/04 (2013.01);
Abstract
The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.