The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Jun. 25, 2012
Applicants:
Louis Clark, Redwood City, CA (US);
Trish Choudhary, Redwood City, CA (US);
Inventors:
Louis Clark, Redwood City, CA (US);
Trish Choudhary, Redwood City, CA (US);
Assignee:
Codexis, Inc., Redwood City, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 9/02 (2006.01); C12P 19/34 (2006.01); C12N 9/42 (2006.01); C12N 9/24 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1034 (2013.01); C12N 9/0004 (2013.01); C12N 9/24 (2013.01); C12N 9/2434 (2013.01); C12N 15/1027 (2013.01); C12P 19/34 (2013.01);
Abstract
Region shuffling methods for efficiently introducing diversity and exploring sequence space are described. Libraries produced directly from these methods contain high fractions of protein variants harboring multiple beneficial mutations. Typically, the methods produce these variants efficiently without the need for sequencing beneficial mutants identified at intermediate stages of the process.