The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Mar. 29, 2012
Janet Davis, Skillman, NJ (US);
Jiajian Liu, Skillman, NJ (US);
Christine Parmenter, Skillman, NJ (US);
Pascal Ghislain André Bonnet, Beerse, BE;
Janet Davis, Skillman, NJ (US);
Jiajian Liu, Skillman, NJ (US);
Christine Parmenter, Skillman, NJ (US);
Pascal Ghislain André Bonnet, Beerse, BE;
Janssen Biotech, Inc., Horsham, PA (US);
Abstract
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.