The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Sep. 07, 2009
Applicants:
Camilo Colaco, Cambridge, GB;
Kamram Salim, Cambridge, GB;
Inventors:
Camilo Colaco, Cambridge, GB;
Kamram Salim, Cambridge, GB;
Assignee:
IMMUNOBIOLOGY LTD, Cambridge, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/32 (2006.01); A61K 39/00 (2006.01); C07K 1/18 (2006.01); A61K 39/04 (2006.01); A61K 39/095 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
C07K 1/18 (2013.01); A61K 39/0011 (2013.01); A61K 39/04 (2013.01); A61K 39/095 (2013.01); C07K 14/00 (2013.01); A61K 2039/5256 (2013.01); C07K 2319/30 (2013.01); C12N 2710/14143 (2013.01); C12N 2760/16122 (2013.01); C12N 2770/24222 (2013.01);
Abstract
The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.