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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9593129 B1

PDFFull Text
Date of Patent:
Mar. 14, 2017

Filed:

Jan. 27, 2016

Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Michael D. Bartberger, Sherman Oaks, CA (US);

Ana Gonzalez Buenrostro, San Mateo, CA (US);

Hilary Plake Beck, Emerald Hills, CA (US);

Xiaoqi Chen, Palo Alto, CA (US);

Richard Victor Connors, Scottsdale, AZ (US);

Jeffrey Deignan, San Francisco, CA (US);

Jason A. Duquette, Millbrae, CA (US);

John Eksterowicz, San Francisco, CA (US);

Benjamin Fisher, San Mateo, CA (US);

Brian M. Fox, Brisbane, CA (US);

Jiasheng Fu, Foster City, CA (US);

Zice Fu, Foster City, CA (US);

Felix Gonzalez Lopez De Turiso, Cambridge, MA (US);

Michael W. Gribble, Jr., San Francisco, CA (US);

Darin J. Gustin, Half Moon Bay, CA (US);

Julie A. Heath, Chico, CA (US);

Xin Huang, Wellesley, MA (US);

XianYun Jiao, Belmont, CA (US);

Michael G. Johnson, San Francisco, CA (US);

Frank Kayser, San Francisco, CA (US);

David John Kopecky, Studio City, CA (US);

SuJen Lai, Boston, MA (US);

Yihong Li, Johns Creek, GA (US);

Zhihong Li, Millbrae, CA (US);

Jiwen Liu, Foster City, CA (US);

Jonathan D. Low, Reseda, CA (US);

Brian S. Lucas, Arlington, MA (US);

Zhihua Ma, Lexington, MA (US);

Lawrence R. McGee, Pacifica, CA (US);

Joel McIntosh, Pacifica, CA (US);

Dustin L. McMinn, Pacifica, CA (US);

Julio C. Medina, San Carlos, CA (US);

Jeffrey Thomas Mihalic, San Francisco, CA (US);

Steven H. Olson, Millbrae, CA (US);

Yosup Rew, Foster City, CA (US);

Philip M. Roveto, Albuquerque, NM (US);

Daqing Sun, Foster City, CA (US);

Xiaodong Wang, Johns Creek, GA (US);

Yingcai Wang, Millbrae, CA (US);

Xuelei Yan, Foster City, CA (US);

Ming Yu, Foster City, CA (US);

Jiang Zhu, Palo Alto, CA (US);

Assignee:

Amgen, Inc., Thousand Oaks, CA (US);

Attorney:

Markus Bergauer

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 498/14 (2006.01); C07D 221/20 (2006.01); C07D 471/10 (2006.01); C07D 211/76 (2006.01); C07D 279/02 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 407/04 (2006.01); C07D 407/06 (2006.01); C07D 409/04 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 498/08 (2006.01); C07D 498/20 (2006.01); C07D 405/04 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 491/08 (2006.01); C07D 491/153 (2006.01);
U.S. Cl.
CPC ...
C07D 498/14 (2013.01); C07D 211/76 (2013.01); C07D 221/20 (2013.01); C07D 279/02 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 407/04 (2013.01); C07D 407/06 (2013.01); C07D 409/04 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 491/08 (2013.01); C07D 491/153 (2013.01); C07D 498/08 (2013.01); C07D 498/20 (2013.01);
Abstract

The present invention provides MDM2 inhibitor compounds of Formula I,

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