The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 14, 2017

Filed:

Aug. 02, 2013
Applicant:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Benjamin Stone Amidon, Arlington, MA (US);

David P. Cardin, Wilmington, DE;

Alexandra E. Gould, Cambridge, MA (US);

Paul D. Greenspan, Acton, MA (US);

Sean J. Harrison, Belmont, MA (US);

Assignee:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 35/04 (2006.01); A61P 37/06 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01);
Abstract

Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*is —H or —CH; and Y is Formula (II) or Formula (III), wherein Ris —H, —CHor Calkyloxycarbonyl; and R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.


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