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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9593110 B1

PDFFull Text
Date of Patent:
Mar. 14, 2017

Filed:

Jan. 29, 2015

Neprilysin inhibitors

Applicants:

Melissa Fleury, San Francisco, CA (US);

Anne-marie Beausoliel, San Mateo, CA (US);

Adam D. Hughes, Belmont, CA (US);

Daniel D. Long, San Francisco, CA (US);

Donna A. A. Wilton, San Francisco, CA (US);

Inventors:

Melissa Fleury, San Francisco, CA (US);

Anne-Marie Beausoliel, San Mateo, CA (US);

Adam D. Hughes, Belmont, CA (US);

Daniel D. Long, San Francisco, CA (US);

Donna A. A. Wilton, San Francisco, CA (US);

Assignee:

Theravence Biopharma R&D IP, LLC, South San Francisco, CA (US);

Attorneys:

Jeffrey A. Hagenah

Wendy Petka

Primary Examiner:

Alicia L Otton

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
C07D 249/04 (2006.01); C07D 231/14 (2006.01); C07D 263/34 (2006.01); C07D 271/07 (2006.01); C07D 213/81 (2006.01); A61K 31/422 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 31/42 (2006.01); A61K 31/4245 (2006.01); C07D 471/04 (2006.01); C07D 261/18 (2006.01); C07D 249/10 (2006.01); A61K 31/415 (2006.01); A61K 31/421 (2006.01); A61K 31/44 (2006.01); C07D 239/28 (2006.01); A61K 31/505 (2006.01); C07D 275/03 (2006.01); A61K 31/425 (2006.01); A61K 31/437 (2006.01); C07D 403/04 (2006.01); A61K 31/4985 (2006.01); C07D 403/12 (2006.01); A61K 45/06 (2006.01); C07D 405/14 (2006.01); C07D 309/40 (2006.01); C07C 271/22 (2006.01); C07D 319/06 (2006.01); C07D 231/18 (2006.01); C07D 231/20 (2006.01); C07D 233/70 (2006.01); C07D 233/90 (2006.01); C07D 401/04 (2006.01); C07D 235/08 (2006.01); C07D 403/06 (2006.01); C07D 237/14 (2006.01); C07D 239/34 (2006.01); C07D 405/12 (2006.01); C07C 229/34 (2006.01); C07D 249/12 (2006.01); C07D 249/18 (2006.01); C07D 261/12 (2006.01); C07D 263/18 (2006.01); C07D 295/10 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/415 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/421 (2013.01); A61K 31/425 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/44 (2013.01); A61K 31/4985 (2013.01); A61K 31/505 (2013.01); A61K 45/06 (2013.01); C07C 229/34 (2013.01); C07C 271/22 (2013.01); C07D 213/81 (2013.01); C07D 231/14 (2013.01); C07D 231/18 (2013.01); C07D 231/20 (2013.01); C07D 233/70 (2013.01); C07D 233/90 (2013.01); C07D 235/08 (2013.01); C07D 237/14 (2013.01); C07D 239/28 (2013.01); C07D 239/34 (2013.01); C07D 249/04 (2013.01); C07D 249/10 (2013.01); C07D 249/12 (2013.01); C07D 249/18 (2013.01); C07D 261/12 (2013.01); C07D 261/18 (2013.01); C07D 263/18 (2013.01); C07D 263/34 (2013.01); C07D 271/07 (2013.01); C07D 275/03 (2013.01); C07D 295/10 (2013.01); C07D 309/40 (2013.01); C07D 319/06 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01);
Abstract

In one aspect, the invention relates to compounds having the formula I: where R-Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

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