The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9593081 B1

Date of Patent:

Mar. 14, 2017

Filed:

Jun. 12, 2014

4-alkynyl imidazole derivative and medicine comprising same as active ingredient

Applicant:

Kaken Pharmaceutical Co., Ltd., Tokyo, JP;

Inventors:

Satoru Ikegami, Kyoto, JP;

Atsushi Watanabe, Kyoto, JP;

Kimio Hirano, Kyoto, JP;

Tadashi Ohyama, Kyoto, JP;

Assignee:

KAKEN PHARMACEUTICAL CO., LTD., Tokyo, JP;

Attorney:

Sughrue Mion, PLLC

Primary Examiner:

Laura L Stockton

Int. Cl.

CPC ...

C07D 233/90 (2006.01); C07D 403/12 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01);

U.S. Cl.

CPC ...

C07D 233/90 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01);

Abstract

There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the treatment of diseases associated with the EP4 receptor, for example, as anti-inflammatory and/or analgesic drugs for inflammatory diseases and diseases that involve various kinds of pains, and further as pharmaceuticals for the treatment of immune diseases that result from inflammations as evoked by tissue destruction due to the activation of Th1 cells and/or Th17 cells:

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