The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
Nov. 22, 2012
Applicant:
Royal College of Surgeons IN Ireland, Dublin, IE;
Inventor:
Mauro Adamo, Dublin, IE;
Assignee:
Royal College of Surgeons In Ireland, Dublin, IE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 227/32 (2006.01); C07C 227/02 (2006.01); C07C 227/04 (2006.01); C07D 261/14 (2006.01); C07D 453/04 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
C07C 227/32 (2013.01); C07C 227/02 (2013.01); C07C 227/04 (2013.01); C07D 261/14 (2013.01); C07D 401/06 (2013.01); C07D 453/04 (2013.01); C07B 2200/07 (2013.01); C07C 2101/14 (2013.01);
Abstract
The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein Ris selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.