The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 14, 2017

Filed:

Oct. 17, 2014
Applicant:

The University of Chicago, Chicago, IL (US);

Inventors:

Rustem F. Ismagilov, Pasadena, CA (US);

Joshua David Tice, Webster, NY (US);

Cory John Gerdts, Chicago, IL (US);

Bo Zheng, Chicago, IL (US);

Assignee:

The University of Chicago, Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/10 (2006.01); B01L 3/00 (2006.01); B01F 5/06 (2006.01); B01F 13/00 (2006.01); B01J 19/00 (2006.01); B82Y 30/00 (2011.01); G01N 35/08 (2006.01); G01N 1/28 (2006.01); B01D 9/00 (2006.01); C07K 14/43 (2006.01); C12N 9/36 (2006.01); C30B 7/14 (2006.01); C30B 29/54 (2006.01); C30B 29/58 (2006.01); B01J 14/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502784 (2013.01); B01D 9/0072 (2013.01); B01F 5/0646 (2013.01); B01F 5/0647 (2013.01); B01F 13/0071 (2013.01); B01J 14/00 (2013.01); B01J 19/0046 (2013.01); B01J 19/0093 (2013.01); B01L 3/50273 (2013.01); B01L 3/502715 (2013.01); B82Y 30/00 (2013.01); C07K 14/43 (2013.01); C12N 9/2462 (2013.01); C12Q 1/6806 (2013.01); C30B 7/14 (2013.01); C30B 29/54 (2013.01); C30B 29/58 (2013.01); G01N 1/28 (2013.01); G01N 35/08 (2013.01); B01D 2009/0086 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/00286 (2013.01); B01J 2219/00576 (2013.01); B01J 2219/00585 (2013.01); B01J 2219/00599 (2013.01); B01J 2219/00722 (2013.01); B01J 2219/00725 (2013.01); B01J 2219/00736 (2013.01); B01J 2219/00756 (2013.01); B01J 2219/00783 (2013.01); B01J 2219/00837 (2013.01); B01J 2219/00869 (2013.01); B01J 2219/00889 (2013.01); B01J 2219/00891 (2013.01); B01J 2219/00894 (2013.01); B01J 2219/00903 (2013.01); B01J 2219/00975 (2013.01); B01J 2219/00977 (2013.01); B01L 2200/0673 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/0487 (2013.01); C12Y 302/01017 (2013.01); Y10T 117/10 (2015.01); Y10T 137/0318 (2015.04); Y10T 436/117497 (2015.01); Y10T 436/143333 (2015.01); Y10T 436/25 (2015.01);
Abstract

A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.


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