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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9592295 B1

PDFFull Text
Date of Patent:
Mar. 14, 2017

Filed:

Feb. 26, 2016

Reversely thermo-reversible hydrogel compositions

Applicant:

Broda Technologies Co., Ltd., Shanghai, CN;

Inventors:

Shao Xiang Lu, Plainsboro, NJ (US);

Jeffrey Lu, Plainsboro, NJ (US);

Letian Liu, Plainsboro, NJ (US);

Assignee:

Broda Technologies Co., Ltd., Shanghai, CN;

Attorney:

RatnerPrestia

Primary Examiner:

Jianfeng Song

Int. Cl.
CPC ...
A61K 47/10 (2006.01); A61K 31/565 (2006.01); A61K 31/60 (2006.01); A61K 31/573 (2006.01); A61K 31/416 (2006.01); A61Q 19/08 (2006.01); A61K 8/368 (2006.01); A61Q 1/02 (2006.01); A61K 8/90 (2006.01); A01N 37/18 (2006.01); A61K 8/37 (2006.01); A61Q 17/04 (2006.01); A61Q 1/00 (2006.01); A61Q 1/04 (2006.01); A61Q 5/00 (2006.01); A61Q 5/10 (2006.01); A61Q 9/02 (2006.01); A61Q 9/04 (2006.01); A61Q 11/00 (2006.01); A61Q 13/00 (2006.01); A61Q 15/00 (2006.01); A61Q 17/02 (2006.01); A61Q 19/00 (2006.01); A61K 8/97 (2006.01); A61K 47/34 (2006.01); A61K 8/02 (2006.01); A61K 31/137 (2006.01); A61K 31/167 (2006.01); A61K 31/506 (2006.01); A61K 31/58 (2006.01); A01N 25/00 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 8/39 (2006.01); A61Q 7/00 (2006.01); A61K 8/86 (2006.01); A61K 8/04 (2006.01); C08J 3/075 (2006.01); A61K 8/34 (2006.01); A61K 47/48 (2006.01); A61Q 1/12 (2006.01); C08L 71/02 (2006.01); A61K 47/14 (2006.01);
U.S. Cl.
CPC ...
A61K 47/10 (2013.01); A01N 25/00 (2013.01); A01N 37/18 (2013.01); A61K 8/02 (2013.01); A61K 8/042 (2013.01); A61K 8/345 (2013.01); A61K 8/368 (2013.01); A61K 8/37 (2013.01); A61K 8/39 (2013.01); A61K 8/86 (2013.01); A61K 8/90 (2013.01); A61K 8/97 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 31/137 (2013.01); A61K 31/167 (2013.01); A61K 31/416 (2013.01); A61K 31/506 (2013.01); A61K 31/565 (2013.01); A61K 31/573 (2013.01); A61K 31/58 (2013.01); A61K 31/60 (2013.01); A61K 47/14 (2013.01); A61K 47/34 (2013.01); A61K 47/48215 (2013.01); A61Q 1/00 (2013.01); A61Q 1/02 (2013.01); A61Q 1/04 (2013.01); A61Q 1/12 (2013.01); A61Q 5/00 (2013.01); A61Q 5/10 (2013.01); A61Q 7/00 (2013.01); A61Q 9/02 (2013.01); A61Q 9/04 (2013.01); A61Q 11/00 (2013.01); A61Q 13/00 (2013.01); A61Q 15/00 (2013.01); A61Q 17/02 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/08 (2013.01); C08J 3/075 (2013.01); C08L 71/02 (2013.01); A61K 2800/54 (2013.01); A61K 2800/548 (2013.01); C08G 2210/00 (2013.01); C08G 2650/58 (2013.01); C08L 2203/02 (2013.01);
Abstract

A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.

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