The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2017
Filed:
May. 23, 2012
Timothy Hla, Avon, CT (US);
Hideru Obinata, New York, NY (US);
Sylvain Galvani, New York, NY (US);
Bjorn Dahlback, Malmo, SE;
Lars BO Nielsen, Copenhagen K, DK;
Christina Christoffersen, Copenhagen K, DK;
Victoria Blaho, Ithaca, NY (US);
Timothy Hla, Avon, CT (US);
Hideru Obinata, New York, NY (US);
Sylvain Galvani, New York, NY (US);
Bjorn Dahlback, Malmo, SE;
Lars Bo Nielsen, Copenhagen K, DK;
Christina Christoffersen, Copenhagen K, DK;
Victoria Blaho, Ithaca, NY (US);
CORNELL UNIVERSITY, Ithaca, NY (US);
Abstract
Apolipoprotein M forms a complex with sphingosine-1-phosphate (S1P) and is the carrier of S1P in high density lipoprotein particles and mediates its endothelial protective effect. Increasing the concentration of the apoM/S1P complex by administering it, either alone or in HDL particles, can prevent or treat diseases caused by endothelial cell injury, including inflammatory diseases, sepsis, atherosclerosis and acute lung injury, ischemic heart disease, stroke, vital organ failure after ischemic stress.