IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9592221 B1

PDFFull Text
Date of Patent:
Mar. 14, 2017

Filed:

Mar. 08, 2016

Antibacterial agents: aryl myxopyronin derivatives

Applicants:

Rutgers, the State University of New Jersey, New Brunswick, NJ (US);

Provid Pharmaceuticals Inc., Monmouth Junction, NJ (US);

Inventors:

Richard H. Ebright, New Brunswick, NJ (US);

Yon W. Ebright, New Brunswick, NJ (US);

Juan Shen, New Brunswick, NJ (US);

James Bacci, Monmouth Junction, NJ (US);

Anne-Cecile Hiebel, Monmouth Junction, NJ (US);

William Solvibile, Monmouth Junction, NJ (US);

Christopher Self, Monmouth Junction, NJ (US);

Gary Olson, Monmouth Junction, NJ (US);

Assignees:

Rutgers, The State University of New Jersey, New Brunswick, NJ (US);

Provid Pharmaceuticals Inc., Monmouth Junction, NJ (US);

Attorney:

Viksnins Harris & Padys PLLP

Primary Examiner:

Nizal Chandrakumar

Int. Cl.
CPC ...
A01N 43/16 (2006.01); A61K 31/366 (2006.01); C07D 309/38 (2006.01); C07D 405/06 (2006.01); C07D 407/06 (2006.01); C07D 407/12 (2006.01); C07D 409/06 (2006.01); C07D 417/06 (2006.01); C07D 309/36 (2006.01); C07D 405/12 (2006.01); A61K 31/381 (2006.01); A61K 31/4025 (2006.01); A61K 31/404 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4433 (2006.01);
U.S. Cl.
CPC ...
A61K 31/366 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61K 31/4025 (2013.01); A61K 31/4178 (2013.01); A61K 31/427 (2013.01); A61K 31/4433 (2013.01); C07D 309/36 (2013.01); C07D 309/38 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 407/06 (2013.01); C07D 407/12 (2013.01); C07D 409/06 (2013.01); C07D 417/06 (2013.01);
Abstract

The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

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